When answering this question, focus on specific examples from your past experience where you successfully scaled up a process from the lab to production. Highlight the challenges you faced, the strategies you employed to overcome them, and the outcomes of your efforts. Mention any relevant technologies, methodologies, or tools you used, and emphasize your understanding of the critical factors involved in scale-up, such as maintaining product consistency, optimizing yield, and ensuring regulatory compliance.
Example:
"In my previous role at XYZ Biotech, I was responsible for scaling up a fermentation process for a new biologic drug. Initially, I conducted small-scale experiments to optimize the growth conditions and nutrient concentrations. Once we had a robust lab-scale process, I worked on scaling it up to a 500-liter bioreactor. One of the main challenges was maintaining the same level of oxygen transfer and mixing efficiency at a larger scale. To address this, I collaborated with the engineering team to design custom impellers and optimized the aeration strategy. As a result, we achieved a consistent product yield and quality, which met all regulatory requirements and significantly reduced production costs."
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