This question is asked to gauge your familiarity with one of the core components of bioprocess engineering. When answering, focus on specific projects or roles where you have designed, operated, or optimized bioreactors. Mention any particular types of bioreactors you have worked with (e.g., stirred-tank, airlift, or packed-bed), the scale of operations (lab-scale, pilot-scale, or industrial-scale), and any challenges you faced and how you overcame them. For example:
"In my previous role at XYZ Biotech, I was responsible for the design and operation of a 200-liter stirred-tank bioreactor used for the production of monoclonal antibodies. I optimized the oxygen transfer rate and implemented a real-time monitoring system to ensure consistent product quality. One of the challenges I faced was maintaining sterility during scale-up, which I addressed by developing a robust cleaning and sterilization protocol."
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