When answering this question, focus on specific downstream processing techniques you have experience with, such as chromatography, centrifugation, filtration, and crystallization. Discuss the context in which you used these techniques, the challenges you faced, and how you overcame them. Provide examples of successful projects or improvements you made to existing processes. Highlight your understanding of the importance of downstream processing in ensuring product quality and yield. For example:
"In my previous role at XYZ Biotech, I was responsible for optimizing the chromatography steps in the purification of monoclonal antibodies. I implemented a new buffer system that increased the yield by 15% and reduced impurities by 10%. Additionally, I worked on scaling up the centrifugation process, which involved troubleshooting issues related to shear sensitivity of the product. By adjusting the centrifuge parameters, I was able to maintain product integrity and improve overall process efficiency."
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