What steps do you take to assess the severity and causality of adverse drug reactions?

Your Answer

How To Answer This Question?

When answering this question, it's important to demonstrate a systematic approach to assessing adverse drug reactions (ADRs). Here's a structured way to respond:

1. Initial Assessment: Start by gathering comprehensive patient information, including medical history, current medications, and the timeline of the adverse event.

2. Severity Assessment: Explain how you categorize the severity of the ADR (e.g., mild, moderate, severe) based on clinical guidelines and the impact on the patient's health.

3. Causality Assessment: Discuss the methods you use to determine the likelihood that the drug caused the adverse event. Mention tools like the Naranjo Algorithm or WHO-UMC causality assessment system.

4. Documentation and Reporting: Highlight the importance of thorough documentation and timely reporting to regulatory authorities and pharmaceutical companies.

5. Follow-Up: Emphasize the need for follow-up with the patient to monitor the resolution of the ADR and any long-term effects.

Example Answer:

"To assess the severity and causality of adverse drug reactions, I start with a thorough initial assessment, collecting detailed patient information and the timeline of the adverse event. I then categorize the severity of the reaction based on clinical guidelines. For causality assessment, I use tools like the Naranjo Algorithm to determine the likelihood that the drug caused the event. I ensure all findings are meticulously documented and reported to the relevant authorities. Finally, I follow up with the patient to monitor the resolution of the ADR and any long-term effects."